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A current discovery highlighted a novel job for intracellular MIF in regulating the accumulation of misfolded Cu/Zn superoxide dismutase (SOD1). Mutations in SOD1 are linked to twenty% from the check here conditions of familial amyotrophic lateral sclerosis, and that is characterised by loss of motor neurons [72]. Springer mother nature continues
Constitutively expressed by a wide spectrum of cells and tissues, like monocytes and macrophages, MIF is rapidly released immediately after publicity to microbial goods and Professional-inflammatory mediators, and in response to worry. depending on these findings, enhancing the CD74 pathway may represent a novel therapy approach for selling healin